Biologically Active Natural Products. Pharmaceuticals by Stephen J. Cutler, Horace G. Cutler

By Stephen J. Cutler, Horace G. Cutler

This e-book demonstrates the connections among agrochemicals and prescribed drugs and explores using crops and plant items within the formula and improvement of prescribed drugs.

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1 Introduction This chapter describes the background and rationale and some of the results from the first 4 years of an International Cooperative Biodiversity Group (ICBG) working in the South American nation of Suriname. Although the major focus will be on the chemistry that was carried out, the cooperative nature of the project and the importance of the results achieved in other areas demand that some account of the work of other members of the group be included. Before describing the research that was done, it will be helpful to review the overall rationale for this work.

16-19 In the remaining sections of this chapter, brief details of the experimental approaches to our separate projects on the discovery of novel plant-derived cancer chemotherapeutic agents and cancer chemopreventives will be provided in turn, with emphasis of the phytochemical aspects. A number of novel bioactive plant secondary metabolites will be presented that have been isolated via activity-guided fractionation techniques in our recent work on these two projects. ”20 A group at the College of Pharmacy, University of Illinois at Chicago — senior investigators Drs.

Procumbens, and was determined as possessing a C-3-attached benzoyl group. The initial nonpolar crude extracts of P. procumbens exhibited significant activity in an antiestrogen-binding site (AEBS) assay, with compounds 17 and 18 being of equivalent potency in this regard, and both slightly less potent than 19. ) Pers. (Leguminosae) as inducers of quinone reductase, using Hepa 1c1c7 hepatoma cells. A novel isoflavone (20) and the novel chalcone, (+)-tephropurpurin (21), were among eight compounds isolated as inducers of quinone reductase from this plant source.

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