Antiepileptic Drug Discovery: Novel Approaches by Alan Talevi, Luisa Rocha

By Alan Talevi, Luisa Rocha

This thorough quantity delves into antiepileptic drug discovery with a accomplished choice of cutting edge techniques for the advance of antiepileptic treatments, concentrating on novel molecular objectives for antiepileptic medications, computer-aided methods for the identity of recent drug applicants, and healing concepts to beat refractory epilepsy. The final part illustrates the aptitude merits that community pharmacology and rational drug repurposing may carry to the antiepileptic drug discovery neighborhood. Written for the Methods in Pharmacology and Toxicology sequence, chapters comprise the type of specified description and implementation recommendation to make sure leads to the laboratory.
Authoritative and sensible, Antiepileptic Drug Discovery: Novel Approaches goals to supply medicinal chemists, pharmacologists, and different researchers with the instruments have to extra discover the learn of pharmacoresistant epilepsy and the invention of latest antiepileptic drugs.

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Smith SEP, Li J, Garbett K et al (2007) Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 27:10695–10702 89. Pineda E, Shin D, You SJ et al (2013) Maternal immune activation promotes hippocampal kindling epileptogenesis in mice. Ann Neurol 74:11–19 90. Washington J, Kumar U, Medel-Matus J-S et al (2015) Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice.

J Neuroimmunol 207:111–116 94. Ashwood P, Krakowiak P, Hertz-Picciotto I et al (2011) Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 25:40–45 95. Xu N, Li X, Zhong Y (2015) Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders. Mediators Inflamm 2015: 531518 96. Rozen S, Skaletsky H (2000) Primer3 on the WWW for general users and for biologist programmers.

It is also involved in neuronal excitability and epileptogenesis [65, 66]. Rapamycin is an immunosuppressant that specifically inhibits mTOR pathway. In addition, it decreases the expression of IL-1β and TNF-α, very likely through the inhibition of the activation of NF-kB [67] (Fig. 5). In patients, rapamycin has been found to decrease seizures associated with tuberous sclerosis, infantile spasms, seizures secondary to neonatal hypoxia, absence seizures, and temporal lobe epilepsy [68]. Results of experimental models confirm its antiepileptic effects [69].

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